The Brewers bullpen blew a lead, giving up two home runs in the ninth inning of a 4-2 loss to Arizona Wednesday.
The disappointing regular season ends with Milwaukee putting up an 86-and-76 record.
That breaks a streak of four straight seasons the Brewers had made the playoffs.
Starter Corbin Burnes struck out five in three hitless innings to become the first Brewer pitcher to ever lead the league in strikeouts.
He had 243.
Rowdy Tellez popped his 35th home.
Trevor Gott took the loss.